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ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort.

TitleABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort.
Publication TypeJournal Article
Year of Publication2014
AuthorsAlexander, KS, Zakai, NA, Gillett, S, McClure, LA, Wadley, V, Unverzagt, F, Cushman, M
JournalNeurology
Volume83
Issue14
Pagination1271-6
Date Published2014 Sep 30
ISSN1526-632X
KeywordsABO Blood-Group System, African Americans, Blood Gas Analysis, Case-Control Studies, Cognition Disorders, European Continental Ancestry Group, Factor VIII, Female, Follow-Up Studies, Genetic Predisposition to Disease, Genotyping Techniques, Humans, Incidence, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, United States
Abstract

OBJECTIVE: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.METHODS: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.RESULTS: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15-2.90; and 1.24, 95% CI 1.10-1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119-165) compared with O (104 IU/dL; 95% CI 101-107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation -30% to 68%).CONCLUSIONS: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.

DOI10.1212/WNL.0000000000000844
Alternate JournalNeurology
PubMed ID25209581
PubMed Central IDPMC4180487
Grant ListP30 DK079626 / DK / NIDDK NIH HHS / United States
K08HL096841 / HL / NHLBI NIH HHS / United States
T32HL007594-27 / HL / NHLBI NIH HHS / United States
U01 NS041588 / NS / NINDS NIH HHS / United States