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Aspirin use and long-term rates of sepsis: A population-based cohort study.

TitleAspirin use and long-term rates of sepsis: A population-based cohort study.
Publication TypeJournal Article
Year of Publication2018
AuthorsHsu, J, Donnelly, JP, Chaudhary, NS, Moore, JX, Safford, MM, Kim, J, Wang, HE
JournalPLoS One
Volume13
Issue4
Paginatione0194829
Date Published2018
ISSN1932-6203
KeywordsAged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Cohort Studies, Comorbidity, Female, Humans, Male, Middle Aged, Population Surveillance, Proportional Hazards Models, Sepsis, Socioeconomic Factors, Southeastern United States, Time Factors
Abstract

OBJECTIVE: Sepsis is the syndrome of life-threatening organ dysfunction resulting from dysregulated host response to infection. Aspirin, an anti-inflammatory agent, may play a role in attenuating the inflammatory response during infection. We evaluated the association between aspirin use and long-term rates of sepsis as well as sepsis outcomes.METHODS: We analyzed data from 30,239 adults ≥45 years old in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. The primary exposure was aspirin use, identified via patient interview. The primary outcome was sepsis hospitalization, defined as admission for infection with two or more systemic inflammatory response syndrome criteria. We fit Cox proportional hazards models assessing the association between aspirin use and rates of sepsis, adjusted for participant demographics, health behaviors, chronic medical conditions, medication adherence, and biomarkers. We used a propensity-matched analysis and a series of sensitivity analyses to assess the robustness of our results. We also examined risk of organ dysfunction and hospital mortality during hospitalization for sepsis.RESULTS: Among 29,690 REGARDS participants with follow-up data available, 43% reported aspirin use (n = 12,869). Aspirin users had higher sepsis rates (hazard ratio 1.35; 95% CI: 1.22-1.49) but this association was attenuated following adjustment for potential confounders (adjusted HR 0.99; 95% CI: 0.88-1.12). We obtained similar results in propensity-matched and sensitivity analyses. Among sepsis hospitalizations, aspirin use was not associated with organ dysfunction or hospital death.CONCLUSIONS: In the REGARDS cohort, baseline aspirin use was not associated with long-term rates of sepsis.

DOI10.1371/journal.pone.0194829
Alternate JournalPLoS ONE
PubMed ID29668690
PubMed Central IDPMC5905958
Grant ListTL1 TR001418 / TR / NCATS NIH HHS / United States
R01 NR012726 / NR / NINR NIH HHS / United States
R25 CA047888 / CA / NCI NIH HHS / United States
U01 NS041588 / NS / NINDS NIH HHS / United States
UL1 RR025777 / RR / NCRR NIH HHS / United States
UL1 TR001417 / TR / NCATS NIH HHS / United States
F31 GM122180 / GM / NIGMS NIH HHS / United States