|Title||Fine particulate air pollution and premature ventricular contractions: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||O'Neal, WT, Soliman, EZ, Efird, JT, Howard, VJ, Howard, G, McClure, LA|
|Date Published||2017 Apr|
BACKGROUND: It is unknown if higher levels of ambient particulate matter (PM) exposure increase the risk for premature ventricular contractions (PVC) in a population-based study of men and women, and if this relationship varies by race or sex.METHODS: We examined the association of PM <2.5µm in diameter (PM2.5) concentration with PVCs in 26,121 (mean age=64±9.3 years; 55% female; 41% black) participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Estimates of short- (2-week) and long-term (1-year) PM2.5 exposures were computed prior to the baseline visit using geographic information system data on the individual level at the coordinates of study participants' residences. PVCs were identified from baseline electrocardiograms.RESULTS: PVCs were detected in 1719 (6.6%) study participants. Short- (OR=1.08, 95%CI=1.03, 1.14) and long- (OR=1.06, 95%CI=1.01, 1.12) term PM2.5 exposures were associated with PVCs. Interactions were not detected by race or sex. An interaction between short-term PM2.5 exposure and PVCs was detected for those with cardiovascular disease (OR=1.16, 95%CI=1.06, 1.27) compared with those without cardiovascular disease (OR=1.05, 95%CI=0.99, 1.12; p-interaction=0.027).CONCLUSION: Our findings suggest that PM2.5 exposure is associated with an increased risk for PVCs in a biracial population-based study of men and women. We also have identified persons with cardiovascular disease as an at-risk population for PVCs when increases in short-term PM2.5 concentration occur.
|Alternate Journal||Environ. Res.|